Subtle rapid eye movement sleep abnormalities in presymptomatic spinocerebellar ataxia type 2 gene carriers
Identifieur interne : 001368 ( Main/Exploration ); précédent : 001367; suivant : 001369Subtle rapid eye movement sleep abnormalities in presymptomatic spinocerebellar ataxia type 2 gene carriers
Auteurs : Roberto Rodríguez-Labrada [Cuba] ; Luis Velázquez-Perez [Cuba] ; Nalia Canales Ochoa [Cuba] ; Lourdes Galicia Polo [Mexique] ; Reyes Haro Valencia [Mexique] ; Gilberto Sánchez Cruz [Cuba] ; Jacqueline Medrano Montero [Cuba] ; José M. Laffita-Mesa [Cuba] ; Luis E. Almaguer Mederos [Cuba] ; Yanetza González Zaldívar [Cuba] ; Cira Torres Parra [Cuba] ; Arnoy Pe A Acosta [Cuba] ; Tania Cruz Mari O [Cuba]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
- KwdEn :
- Adolescent, Adult, Female, Heterozygote, Humans, Male, Middle Aged, Nerve Tissue Proteins (genetics), Polysomnography, Questionnaires, REM sleep, Sleep, REM (genetics), Spinocerebellar Ataxias (genetics), Spinocerebellar Ataxias (physiopathology), biomarkers, sleep disorders, spinocerebellar ataxias.
- MESH :
- chemical , genetics : Nerve Tissue Proteins.
- genetics : Sleep, REM, Spinocerebellar Ataxias.
- physiopathology : Spinocerebellar Ataxias.
- Adolescent, Adult, Female, Heterozygote, Humans, Male, Middle Aged, Polysomnography, Questionnaires.
Abstract
Rapid eye movement (REM) sleep disorders are commonly associated to patients with spinocerebellar ataxia type 2 (SCA2); however, these abnormalities have not been studied in presymptomatic gene carriers. To determine whether the REM sleep pathology is detectable before clinical manifestation of SCA2 and evaluate it as a preclinical biomarker, we studied 36 presymptomatic SCA2 individuals and 36 controls by video‐polysomnography (VPSG) and sleep questionnaires. Presymptomatic subjects showed significant decrease of REM sleep percentage, REMs density, total sleep time, and sleep efficiency. Aging effect on REM sleep percentage was significant in both groups. There was no correlation between cytosine‐adenine‐guanine (CAG) repeat length and REM sleep. Our findings identified the REM sleep pathology as a prominent herald sign of SCA2, conferring a special importance to VPSG as a sensitive neurophysiological tool to detect early changes associated with SCA2, which contributes to the understanding of disease pathophysiology and the development of therapeutic trials focused on the preclinical disease stage. © 2010 Movement Disorder Society.
Url:
DOI: 10.1002/mds.23409
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="350">350</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D3E49C8F1AF7EB32404051EEB23DE6F57083C5D5</idno><idno type="DOI">10.1002/mds.23409</idno><idno type="ArticleID">MDS23409</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (genetics)</term><term>Polysomnography</term><term>Questionnaires</term><term>REM sleep</term><term>Sleep, REM (genetics)</term><term>Spinocerebellar Ataxias (genetics)</term><term>Spinocerebellar Ataxias (physiopathology)</term><term>biomarkers</term><term>sleep disorders</term><term>spinocerebellar ataxias</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Sleep, REM</term><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Questionnaires</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep disorders are commonly associated to patients with spinocerebellar ataxia type 2 (SCA2); however, these abnormalities have not been studied in presymptomatic gene carriers. To determine whether the REM sleep pathology is detectable before clinical manifestation of SCA2 and evaluate it as a preclinical biomarker, we studied 36 presymptomatic SCA2 individuals and 36 controls by video‐polysomnography (VPSG) and sleep questionnaires. Presymptomatic subjects showed significant decrease of REM sleep percentage, REMs density, total sleep time, and sleep efficiency. Aging effect on REM sleep percentage was significant in both groups. There was no correlation between cytosine‐adenine‐guanine (CAG) repeat length and REM sleep. Our findings identified the REM sleep pathology as a prominent herald sign of SCA2, conferring a special importance to VPSG as a sensitive neurophysiological tool to detect early changes associated with SCA2, which contributes to the understanding of disease pathophysiology and the development of therapeutic trials focused on the preclinical disease stage. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Cuba</li><li>Mexique</li></country></list><tree><country name="Cuba"><noRegion><name sortKey="Rodriguez Abrada, Roberto" sort="Rodriguez Abrada, Roberto" uniqKey="Rodriguez Abrada R" first="Roberto" last="Rodríguez-Labrada">Roberto Rodríguez-Labrada</name></noRegion><name sortKey="Acosta, Arnoy Pe A" sort="Acosta, Arnoy Pe A" uniqKey="Acosta A" first="Arnoy Pe A" last="Acosta">Arnoy Pe A Acosta</name><name sortKey="Cruz, Gilberto Sanchez" sort="Cruz, Gilberto Sanchez" uniqKey="Cruz G" first="Gilberto Sánchez" last="Cruz">Gilberto Sánchez Cruz</name><name sortKey="Laffita Esa, Jose M" sort="Laffita Esa, Jose M" uniqKey="Laffita Esa J" first="José M." last="Laffita-Mesa">José M. Laffita-Mesa</name><name sortKey="Mari O, Tania Cruz" sort="Mari O, Tania Cruz" uniqKey="Mari O T" first="Tania Cruz" last="Mari O">Tania Cruz Mari O</name><name sortKey="Mederos, Luis E Almaguer" sort="Mederos, Luis E Almaguer" uniqKey="Mederos L" first="Luis E. Almaguer" last="Mederos">Luis E. Almaguer Mederos</name><name sortKey="Montero, Jacqueline Medrano" sort="Montero, Jacqueline Medrano" uniqKey="Montero J" first="Jacqueline Medrano" last="Montero">Jacqueline Medrano Montero</name><name sortKey="Ochoa, Nalia Canales" sort="Ochoa, Nalia Canales" uniqKey="Ochoa N" first="Nalia Canales" last="Ochoa">Nalia Canales Ochoa</name><name sortKey="Parra, Cira Torres" sort="Parra, Cira Torres" uniqKey="Parra C" first="Cira Torres" last="Parra">Cira Torres Parra</name><name sortKey="Velazquez Erez, Luis" sort="Velazquez Erez, Luis" uniqKey="Velazquez Erez L" first="Luis" last="Velázquez-Perez">Luis Velázquez-Perez</name><name sortKey="Zaldivar, Yanetza Gonzalez" sort="Zaldivar, Yanetza Gonzalez" uniqKey="Zaldivar Y" first="Yanetza González" last="Zaldívar">Yanetza González Zaldívar</name></country><country name="Mexique"><noRegion><name sortKey="Polo, Lourdes Galicia" sort="Polo, Lourdes Galicia" uniqKey="Polo L" first="Lourdes Galicia" last="Polo">Lourdes Galicia Polo</name></noRegion><name sortKey="Valencia, Reyes Haro" sort="Valencia, Reyes Haro" uniqKey="Valencia R" first="Reyes Haro" last="Valencia">Reyes Haro Valencia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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